POSTDOCTORAL RESEARCHER | CRG ONLINE RECRUITMENT PORTAL

The Institute The Cent re for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.
The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April , the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research ' Award from the European Commission.
This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
Please, check out our Recruitment Policy The role    We are looking for an enthusiastic and highly motivated Postdoctoral Researcher with background in Cell and Molecular Biology and experience in cancer research to join the Vernos group.
We recently identified an enzyme that specifically modifies the spindle microtubules to ensure chromosome segregation fidelity.
This enzyme is systematically downregulated in human cancer suggesting a mechanism that cancer cells exploit to promote aneuploidy and chromosome instability, two hallmarks of particularly aggressive tumours.
The successful candidate will work on a valorisation project for the development of novel anti-tumoral drugs.
He/she will perform screening assays aimed at identifying compounds against this enzyme and characterize their activity against tumour initiation and development using a variety of approaches in cell lines and animal models.
About the l ab  Research in the Vernos lab is directed at understanding the role of the microtubule (MT) network in cell organization and function.
More specifically we want to understand the mechanism underlying spindle assembly and how its dynamics is regulated to ensure chromosome segregation fidelity.
This process is at the core of faithful chromosome segregation and the proliferation of healthy cells as failures of chromosome segregation can generate aneuploidies, a major cause of miscarriages and birth defects in humans as well as a common hallmark of particularly aggressive tumours.
Using a variety of experimental approaches in cells, Xenopus egg extracts and in vitro we have identified and characterized the role of a number of microtubule dependent motors as well as novel pathways that drive MT nucleation and organization in dividing cells.
Our recent work aiming at understanding the role of a post-translational modification of the microtubules during mitosis revealed a novel mechanism that may play a relevant role in cancer, opening also new possibilities for therapeutic intervention.
Whom would we like to hire?   Professional experience    Must Have You have at least two years of experience in the field of cell division  You have proven experience in molecular biology and biochemistry   Desirable but not required/ Nice to have Experience in managing a valorisation project Interest in technology transfer Basic skills in bioinformatics Education and training You hold a Phd in molecular and cell biology  Languages You are proficient in English and Spanish  Technical skills Basic molecular biology techniques  Tissue culture cell handling  Silencing of genes through siRNA or shRNA transfection methods  Optimisation of complex protocols  Competences    Excellent communication and writing skills  Ability to work both in a team and independently  Highly developed organizational skills  Strong drive and commitment to produce high quality experimental data  Creative mind to design experiments and explore data from unexplored angles  The Offer – Working Conditions  Contract d uration.
Technical and scientific activities contract (estimated 1 year)   Estimated annual gross salary.
Salary is commensurate with qualifications and consistent with our pay scales.
Target s tart date.
January   We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.
To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure   All applications must include.
A motivation letter addressed to Dr Isabelle Vernos.
A complete CV including contact details.
Contact details of two referees.
All applications must be addressed to Dr.
Isabelle Vernos and be submitted online through the "Apply" button below.
Selection Process    Pre-selection.
The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS.
It will be merit-based.
Interview.
Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
Offer Letter.
Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline.
Please submit your application by October .