SENIOR SCIENTIST INTERVENTIONAL ONCOLOGY

At Johnson & Johnson, we believe health is everything.
Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.
Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
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At J&J, we are working to build a world without disease.
Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease.
We bring together the best minds and pursue the most promising science, and we collaborate with the world for the health of everyone in it.
Interventional Oncology, is a cross-sector initiative, charged by the Executive Committee of J&J to alter the course of lung cancer and improving survival by intercepting and curing lung cancer.
We are seeking for highly motivated Senior Scientist to complement our Discovery Biology team at Beerse, Belgium.
The successful candidate will join a dynamic, multi-disciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vitro and in vivo.
They will work in new target discovery for lung cancer therapy in order to support and expand the portfolio.
The role includes support of lab based immunological experiments to support the validation of targets in parallel with assay development and the supervision of lab-based staff involved in supporting the pre-clinical assay development.
In addition, responsibilities include designing, implementing, monitoring and analyzing in vivo experimental work conducted internally or externally at contract research organizations.
The role will also require the analysis and presentation of the output of this work to different teams within INTO to support the clinical progression of targets.
ESSENTIAL FUNCTIONS.
(CORE Responsibilities) 1.
Design and execute immune based assay development to support pre-clinical drug development projects, in particular utilizing cancer cell, fibroblast, myeloid and T-cell based co-cultures.
2.
Design and conduct novel research to support target validation of current and future targets in the INTO.
Support biology of project teams as core member.
3.
Supervision of lab-based associate scientist level colleagues to support their pre-clinical validation experiments and career development.
4.
Support pre-clinical in vivo work including design and execution of in vivo experiments, monitoring progress, analysis of results and presentation to INTO leadership teams.
In addition, in vivo model development is an important part of the role.
5.
Support pre-clinical and clinical project team and solution development teams in presentation and explanation of impact of pre-clinical data packages.
6.
Support collaborations with academic investigators including advising on experimentation, analysis of results and conducting complementary experimentation.
Qualifications A minimum of a PhD degree in Life Sciences (Pharmacology, Immunology or Oncology) with a minimum of 5 to 7 years of relevant laboratory-based experience (tumor-inflammation) in industry/biotech or an academic setting is required.
Scientific track-record in field of immune-oncology.
Experience in training/mentoring lab-based associate level scientists.
Proven advanced experience in flowcytometry (panel design, multi-parameter analysis, …).
Highly experienced with hands-on animal handling in oncology-relevant rodent models such as subcutaneous and orthotopic tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
Experience with the adherence to animal welfare and compliance regulations is required.
Drug administration by subcutaneous, intraperitoneal, intravenous tail vein injections and oral gavage.
Blood collection by tail vein, saphenous vein and cardiac puncture.
Perform animal autopsy/dissection and microsurgery, perfusion and tissue collection.
Experienced with cell culture of cancer or immune cells required, experience in endothelial cell biology is a plus.
Experience in tumor metabolism is a plus.
Experienced with bioluminescent imaging, flow cytometry, IHC, ELISA is required.
This position may require occasional weekend, evening, and holiday dosing/animal monitoring.
Other Requirements Must have excellent interpersonal skills, with the ability to interact effectively with people.
Must have strong organizational, data management, and record-keeping skills.
Must have excellent verbal and written communication skills in English Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.
Knowledge of Microsoft Office and Graphpad Prism.
Learning agility and ability to work across projects highly desirable Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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