POSTDOCTORAL POSITION AT THE INSTITUTE FOR NEUROSCIENCE OF CASTILE AND LEON / UNIVERSITY OF SALAMANCA (SPAIN)
Descripción de la oferta de empleo
Our group has extensive experience in the analysis of the PCD mouse, a murine model with different degenerative scenarios of varying severity.
The neuronal death affecting the olfactory bulb of this model mimics the most prevalent human neurodegenerative processes.
late and prolonged in time.
Furthermore, this slow degenerative pattern facilitates the development of new therapeutic strategies.
In this project we aim to demonstrate the neuroprotective capacity of a substance little known in neuroscience, VEGF-B, based on preliminary data from our laboratory.
We want to know whether the systemic application of this neurotrophic factor in our model can reduce neuronal death, under the hypothesis that neuroprotection is not only neural but also peripheral in origin.
Two therapeutic approaches will be compared.
(A) a continuous (classical) intraperitoneal administration of VEGF-B, and (B) a transplantation of healthy bone marrow cells enriched with VEGF-B-producing cells under a ubiquitous promoter.
Objectives to be achieved by the candidate.
To fine-tune the optimal dose of administration of a neuroprotective factor (VEGF-B) in a model of selective neurodegeneration.
To culture hematopoietic cells and perform their genetic transformation, as a cell therapy strategy for the same model.
To compare the potential benefits of both therapeutic approaches.
To perform a gene analysis (by RNA bulk sequencing) of the microglia derived from the transplanted cells.
Specific requirements.
1.
hD in biological or health sciences.
2.
egree or Bachelor’s degree in biological or health sciences.
3.
raining for work with experimental animals in category C.
4.
t least one letter of recommendation from previous supervisors.
Documentation to be submitted and scale.
1.
hotocopy of the DNI or equivalent document in the case of foreigners.
2.
opy of the PhD degree or the corresponding academic certification.
3.
omplete Curriculum Vitae reflecting the curricular merits and experience.
4.
ocumentary evidence of the merits reflected in the CV.
5.
ork Life.
SUBMISSION OF APPLICATIONS.
from to Links of interest.
https://produccioncientifica.
sal.
s/grupos//detalle https://sede.
sal.
s/tablon/anuncio// (please see the annex nº 2)
Detalles de la oferta
- Sin especificar
- 08/11/2024
- 06/02/2025
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